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Pharmacotherapy plays a Central role, and is often combined with lifestyle-related measures. Principles of drug therapy The treatment goals for HKS diseases include: Lowering of blood pressure in hypertension; Reduction of atherogenic lipids (especially LDL cholesterol); Improvement of cardiac performance in heart failure; Prevention of thrombi and emboli; Relief of Angina pectoris. Important Groups Of Drugs ACE inhibitors (e.g., Enalapril, Ramipril) The Renin‑Angiotensin‑aldosterone‑System (RAAS), inhibit, reduce peripheral vascular resistance, and are used especially in the treatment of hypertension and congestive heart failure. They also show a cardioprotective effect. AT1‑receptor blockers (Sartans) (e.g., Losartan, Valsartan) Similar to the ACE inhibitors act on the RAAS, however, are used in patients with intractable side effects (cough) by ACE inhibitors as an Alternative. Beta-blockers (e.g., Metoprolol, Bisoprolol) The heart rate and blood pressure, reduce reduce the oxygen demand of the heart and are in CHD and heart failure is of great importance. Calcium channel blockers (e.g. amlodipine, Diltiazem) Act vasodilatierend and are particularly useful in hypertension and certain forms of Angina pectoris. Diuretics (eg, hydrochlorothiazide, furosemide) Lead to the propagation of the urinary excretion, thus lowering the blood volume and blood pressure. Furosemide is prescribed, especially in advanced heart failure. Statins (e.g., Atorvastatin, Rosuvastatin) The cholesterol synthesis to inhibit the liver metabolism, reduce the levels of LDL‑cholesterol and slow the progression of atherosclerosis. They are also used for secondary prevention after a myocardial infarction or stroke. Anticoagulants Acetylsalicylic acid (Asa): Inhibits platelet aggregation and is used in the prevention of heart attacks and strokes. Clopidogrel: Is often prescribed in combination with aspirin after stent implantation. Anticoagulants (e.g., Warfarin, Rivaroxaban, Dabigatran) Prevent the formation of blood clots, to be applied in the case of atrial fibrillation and to Prosthesis use in the heart. Combination therapy and individual adjustment In practice, medicines are often combined to enhance treatment effectiveness. For example, a combination of an ACE inhibitor and a beta‑blocker in heart failure or a diuretic may be, together with a Sartan in hypertension useful. The choice of medication depends on the individual diagnosis, the risk profile, the comorbidities and the impact. Conclusion The pharmacotherapy of diseases of the cardiovascular system is varied and is based on evidence-based guidelines. A targeted and individually tailored medication may improve Survival, enhance the quality of life and complications preventive encounter. 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